| Title | [Chloroquine cardiotoxicity in long-term lupus therapy in two patients.] | | Author(s) | Saussine A, Loriot MA, Picard C, Lecerf V, Landry J, Scheer I, Voicu S, Leenhardt A, Ducrocq G, Maubec E, Crickx B | | Institution | Service de dermatologie, hôpital Bichat-Claude-Bernard, AP-HP, université Paris-7 Denis-Diderot, 46, rue Henri-Huchard, 75877 Paris cedex 18, France. | | Source | Ann Dermatol Venereol 2009 Jun-Jul; 136(6-7):530-5. | | Abstract | BACKGROUND: The antimalarial compounds chloroquine and hydroxychloroquine are widely used in the treatment of connective tissue diseases and are usually well tolerated. We report two cases of chloroquine cardiotoxicity.
PATIENTS AND METHODS: Two women (aged 43 and 48 years) were treated for 5 years for lupus. They developed severe conduction disturbances requiring a pacemaker. Plasma chloroquine concentrations were abnormally high in both cases. In one case, a genetic polymorphism modulating the activity of a cytochrome involved in chloroquine metabolism (CYP2C8) was identified.
DISCUSSION: Since 1965, 60 cases of occasionally severe cardiotoxicity have been reported following long-term treatment with chloroquine in most cases, but also with hydroxychloroquine. This toxicity must be detected early and close cardiac assessment is required. | | Language | fre | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19560616 |
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